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Buy RAD 140 Powder Online

RAD 140, commonly referred to as Testolone, is a selective androgen receptor modulator (SARM) that is viewed as a promising substitute to traditional testosterone replacement therapy. Characteristic of all SARMs, RAD140 selectively binds to androgen receptors (AR) without manifesting the comprehensive androgenic effects that are typical of substances like testosterone, DHT, or anabolic steroids.

RAD 140 Mechanism of Action

Testolone exhibits a remarkable affinity for the androgen receptor, with a Ki value of 7 nM, which is even higher than DHT. For contextualization, the affinity for the AR for testosterone in a preclinical model was found to be 29 nM, and 10 nM for DHT. Unlike testosterone and many other androgen receptor-mediated anabolic agents, RAD140 is orally bioavailable, thus negating the need for injections to achieve proper absorption.

Observed benefits of RAD 140 in Clinical Research

Introduced in 2010 primarily for osteoporosis treatment, Testolone’s research on rats and primates implies potential supplementary benefits. Some observed effects of the RAD140 SARM include:

• Augmented weight loss
• Enhanced lean muscle protein synthesis
• Increased clearance of beta-amyloid plaques from the brain
• Protective attributes against breast and prostate cancer
• Improved endurance

However, it must be acknowledged that the Food and Drug Administration (FDA) has neither validated nor approved RAD140’s health effects for human use, designating it solely for laboratory research.

Studies involving RAD 140

Some anecdotal evidence has suggested a possibility of testosterone suppression in males due to RAD 140 administration. Various animal studies have been conducted, including:

• A primate study, which proposed that RAD140 might foster modest enhancements in lean muscle mass.
• Research on rats that identified neuroprotective effects of RAD-140, demonstrating its ability to activate ARs in the brain, safeguard hippocampal neurons against cell death, and expedite the removal of beta-amyloid plaques. Another study involving rats discerned that RAD140 could potentially offer neuroprotective benefits that might avert Alzheimer’s disease and similar conditions, and may present a safer alternative to standard testosterone therapy. The group treated with 3 mg/kg RAD140 managed to achieve muscle tissue growth comparable to the group treated with 1 mg/kg Testosterone but exhibited only half the androgenic activity in the prostate.
• In the context of breast cancer treatment, where androgens have been widely explored, the side effects of anabolic steroids have prompted the consideration of SARMs like RAD-140. A preclinical investigation found that RAD140 notably inhibited the growth and proliferation of cancer cells in both in vivo and in vitro models of AR/ER+ breast cancer.