Zepbound (Tirzepatide) is an injectable medication used for chronic weight management in adults. It is also indicated for adults with type 2 diabetes mellitus. Zepbound works by targeting both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, helping to reduce appetite and regulate glucose. It is part of a comprehensive weight management plan that includes a reduced-calorie diet and increased physical activity.

How Zepbound Works

Zepbound contains tirzepatide, a dual agonist that mimics the actions of GIP and GLP-1. These hormones play a role in insulin secretion and appetite regulation. By activating both receptors, Zepbound helps reduce body weight by decreasing food intake and enhancing insulin sensitivity. Additionally, it slows gastric emptying, helping to control glucose levels and prevent spikes after meals.

Zepbound Dosage and Administration

Zepbound is available in various strengths, including 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg. The recommended starting dose is 2.5 mg injected subcutaneously once weekly. After 4 weeks, the dosage should be increased to 5 mg. Depending on the patient’s response and tolerability, the dosage may be further increased by 2.5 mg increments every 4 weeks, up to a maximum dose of 15 mg once weekly.

Zepbound can be injected into the abdomen, thigh, or upper arm. It is important to rotate the injection sites with each dose. Patients should follow their healthcare provider’s instructions closely to achieve optimal results.

Possible Side Effects of Zepbound

Common side effects of Zepbound include:

• Nausea
• Diarrhea
• Vomiting
• Constipation
• Abdominal pain
• Fatigue
• Hair loss
• Injection site reactions

Serious side effects may include:

• Thyroid C-cell tumors
• Pancreatitis
• Acute kidney injury
• Severe gastrointestinal issues
• Hypersensitivity reactions
• Gallbladder disease
• Suicidal thoughts or behavior

If any severe symptoms occur, such as persistent abdominal pain or allergic reactions, contact your healthcare provider immediately.

Drug Interactions

Zepbound may interact with certain medications, including insulin or other drugs that affect glucose levels. It can delay the absorption of oral medications due to its effect on gastric emptying. Patients taking oral contraceptives may need to switch to a non-oral method of contraception or use a barrier method, especially during dose adjustments. Always inform your healthcare provider about any medications or supplements you are taking before starting Zepbound.

Precautions When Using Zepbound

Zepbound is not recommended for patients with a history of medullary thyroid carcinoma (MTC) or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Zepbound has not been studied in patients with a history of pancreatitis, and caution should be taken in individuals with severe gastrointestinal diseases, kidney disease, or gallbladder conditions. Pregnant women should avoid using Zepbound due to the potential risk of harm to the fetus. Speak to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Buying Zepbound from Canada

Many U.S. patients find that purchasing Zepbound from Canada offers a significant cost-saving advantage. Canadian pharmacies often offer lower prices due to different regulations and pricing structures. Here are some steps to ensure a safe purchase:

• Verify the Pharmacy: Ensure that the Canadian pharmacy you are buying from is licensed and reputable. You can ask to speak with a pharmacist to confirm legitimacy.
• Consult Your Doctor: Before purchasing medications from another country, always consult with your healthcare provider to ensure that it is safe and appropriate for your condition.
• Understand U.S. Import Regulations: The U.S. FDA typically allows the importation of a 90-day supply of medication for personal use. Ensure you are compliant with these regulations.
• Have a Valid Prescription: A valid prescription from a U.S. healthcare provider is required to purchase Zepbound from a Canadian pharmacy.

Storage Instructions for Zepbound

Zepbound should be stored in the refrigerator at a temperature between 36°F and 46°F (2°C to 8°C). If necessary, it can be kept at room temperature (up to 86°F or 30°C) for up to 21 days. Do not freeze Zepbound. If it has been frozen, do not use it. Always store Zepbound in its original carton to protect it from light.

Zepbound and Mounjaro: What’s the Difference?

Actually, there is no difference! Zepbound and Mounjaro are brand names for the same medication, tirzepatide. So, if you’re prescribed Zepbound, you can safely use Mounjaro instead.

Why Buy Mounjaro from Canada?

Buying Mounjaro from Canada can save you money. Medications in Canada often cost less than in the U.S. By purchasing Mounjaro from Canadian pharmacies, you can get the same medication (tirzepatide) at a lower price. Prices start at $158.99 per dose.

How to Use Mounjaro

1. Starting Dose: Begin with 2.5 mg once a week for the first 4 weeks.
2. Increase the Dose: After 4 weeks, increase to 5 mg once a week.
3. Adjusting the Dose: Depending on your response and tolerance, your doctor may increase your dose in 2.5 mg increments, up to a maximum of 15 mg per week.
4. Injection Sites: Inject Mounjaro into the skin of your abdomen, thigh, or upper arm. Rotate the injection site each time to avoid skin problems.
5. Missed Dose: If you miss a dose, take it as soon as possible within 4 days. If more than 4 days have passed, skip the missed dose and continue with your next scheduled dose.

Switching from Ozempic to Zepbound

If you’re currently using Ozempic and your doctor suggests switching to Mounjaro, here are some approximate dose equivalents:

• Ozempic 0.25 mg ≈ Zepbound 2.5 mg
• Ozempic 0.5 mg ≈ Zepbound 5 mg or 7.5 mg
• Ozempic 1 mg ≈ Zepbound 10 mg
• Ozempic 2 mg ≈ Zepbound 12.5 mg or 15 mg

These conversions are approximate. Always consult your doctor for personalized advice.

Expected Weight Loss

Many patients start seeing weight loss within the first few weeks of using Zepbound. The amount of weight loss can vary, but clinical trials have shown:

• 5 mg dose: Average weight loss of 15%
• 10 mg dose: Average weight loss of 19.5%
• 15 mg dose: Average weight loss of 20.9%

The medication is available by prescription only and is used as a weekly injection to help with blood sugar management and help reduce the risk of a heart attack or stroke in people with type 2 diabetes. Since semaglutide has shown effectiveness in reducing body weight for those with overweight or obesity, Ozempic may also aid in weight loss. However, Ozempic itself is not FDA approved to treat weight loss alone in patients without a diagnosis of type 2 diabetes.

Wegovy

Wegovy is another injectable medication made with semaglutide (the active ingredient in Ozempic). It’s approved by the FDA for weight management in people with a body mass index or BMI of 27 who have another weight-related condition, such as type 2 diabetes, or those with a BMI of 30 or higher. In recent research, semaglutide showed a higher effectiveness for weight loss than older medications, with the potential for a 15% weight loss after 68 weeks in adults with a BMI of 30 or greater.

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Like Ozempic, Wegovy is also prescription only and taken once a week.

Saxenda

Saxenda, like Ozempic and Wegovy, is a GLP-1 receptor agonist, but it’s made with liraglutide (instead of semaglutide). The medication is also prescription-only and FDA-approved for the treatment of obesity in people aged 12 and older who weigh more than 132 pounds or adults with BMI of 30 or higher. While liraglutide may be slightly less effective than semaglutide, it’s still a potent weight loss medication that could lead to up to an 8% weight loss, says Raoul Manalac, M.D., the senior director of clinical experience at RO, a company offering at-home medical weight loss treatment.

Liraglutide works by helping to decrease appetite and slow the emptying of the stomach, which causes feelings of fullness and leads to lower calorie intake.

Saxenda is a daily injection, while Ozempic and Wegovy are weekly injections.